About 5'-AMP-activated protein kinase catalytic subunit alpha-1
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) is a protein
from Homo sapiens identified by UniProt accession
Q13131, 559 residues long.
MolForge cross-references it against 0 known binders and
581 disease associations.
Target properties
| Protein name | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| UniProt accession | Q13131 |
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| Gene | PRKAA1 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (581)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.36
- mean corpuscular hemoglobin concentration · score 0.35
- gastric carcinoma · score 0.30
- mean corpuscular hemoglobin · score 0.29
- breast adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.28
- cardiovascular disease · score 0.27
- endometrial cancer · score 0.25
- head and neck squamous cell carcinoma · score 0.24
- reticulocyte measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13131-F1 | alphafold | PREDICTED | 79.55 | — |
Amino-acid sequence (559 residues)
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE ITEAKSGTAT PQRSGSVSNY RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG SHTIEFFEMC ANLIKILAQ
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