About Cyclic nucleotide-gated channel alpha-1
Cyclic nucleotide-gated channel alpha-1 (CNGA1) is a protein
from Homo sapiens identified by UniProt accession
P29973, 686 residues long.
MolForge cross-references it against 0 known binders and
220 disease associations.
Target properties
| Protein name | Cyclic nucleotide-gated channel alpha-1 |
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| UniProt accession | P29973 |
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| Gene | CNGA1 |
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| Organism | Homo sapiens |
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| Length | 686 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (220)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.71
- Retinal dystrophy · score 0.53
- Cone rod dystrophy · score 0.28
- Macular dystrophy · score 0.26
- cone-rod dystrophy · score 0.26
- gout · score 0.19
- genetic disorder · score 0.19
- urate measurement · score 0.19
- ovarian cancer · score 0.18
- mean platelet volume · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29973-F1 | alphafold | PREDICTED | 76.22 | — |
Amino-acid sequence (686 residues)
MKNNIINTQQ SFVTMPNVIV PDIEKEIRRM ENGACSSFSE DDDSASTSEE SENENPHARG SFSYKSLRKG GPSQREQYLP GAIALFNVNN SSNKDQEPEE KKKKKKEKKS KSDDKNENKN DPEKKKKKKD KEKKKKEEKS KDKKEEEKKE VVVIDPSGNT YYNWLFCITL PVMYNWTMVI ARACFDELQS DYLEYWLILD YVSDIVYLID MFVRTRTGYL EQGLLVKEEL KLINKYKSNL QFKLDVLSLI PTDLLYFKLG WNYPEIRLNR LLRFSRMFEF FQRTETRTNY PNIFRISNLV MYIVIIIHWN ACVFYSISKA IGFGNDTWVY PDINDPEFGR LARKYVYSLY WSTLTLTTIG ETPPPVRDSE YVFVVVDFLI GVLIFATIVG NIGSMISNMN AARAEFQARI DAIKQYMHFR NVSKDMEKRV IKWFDYLWTN KKTVDEKEVL KYLPDKLRAE IAINVHLDTL KKVRIFADCE AGLLVELVLK LQPQVYSPGD YICKKGDIGR EMYIIKEGKL AVVADDGVTQ FVVLSDGSYF GEISILNIKG SKAGNRRTAN IKSIGYSDLF CLSKDDLMEA LTEYPDAKTM LEEKGKQILM KDGLLDLNIA NAGSDPKDLE EKVTRMEGSV DLLQTRFARI LAEYESMQQK LKQRLTKVEK FLKPLIDTEF SSIEGPGAES GPIDST
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