About Small conductance calcium-activated potassium channel protein 1
Small conductance calcium-activated potassium channel protein 1 (KCNN1) is a protein
from Homo sapiens identified by UniProt accession
Q92952, 543 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Small conductance calcium-activated potassium channel protein 1 |
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| UniProt accession | Q92952 |
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| Gene | KCNN1 |
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| Organism | Homo sapiens |
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| Length | 543 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- mean reticulocyte volume · score 0.18
- mean corpuscular hemoglobin · score 0.16
- atrial fibrillation · score 0.09
- reticulocyte count · score 0.08
- Immature Reticulocyte Fraction Measurement · score 0.06
- reticulocyte measurement · score 0.06
- heel bone mineral density · score 0.05
- hemoglobin D disease · score 0.04
- overhydrated hereditary stomatocytosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92952-F1 | alphafold | PREDICTED | 77.84 | — |
Amino-acid sequence (543 residues)
MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLYSF ALKCLISLST AILLGLVVLY HAREIQLFMV DNGADDWRIA MTCERVFLIS LELAVCAIHP VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL LGRVMLLHSK IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR ETWLIYKHTR LVKKPDQARV RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD ALGASLQALP GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG
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