About Cyclic nucleotide-gated channel alpha-2
Cyclic nucleotide-gated channel alpha-2 (CNGA2) is a protein
from Homo sapiens identified by UniProt accession
Q16280, 664 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Cyclic nucleotide-gated channel alpha-2 |
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| UniProt accession | Q16280 |
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| Gene | CNGA2 |
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| Organism | Homo sapiens |
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| Length | 664 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07
- thrombocytopenia 4 · score 0.07
- Leber congenital amaurosis 10 · score 0.06
- autosomal dominant macrothrombocytopenia · score 0.06
- platelet-type bleeding disorder 15 · score 0.05
- platelet-type bleeding disorder 10 · score 0.05
- asthma, nasal polyps, and aspirin intolerance · score 0.05
- thrombocytopenia 2 · score 0.04
- Absent thumb - short stature - immunodeficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16280-F1 | alphafold | PREDICTED | 77.74 | — |
Amino-acid sequence (664 residues)
MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL QRLADVDAPQ QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG PELQTVTTQE GDGKGDKDGE DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP VLYNWCLLVA RACFSDLQKG YYLVWLVLDY VSDVVYIADL FIRLRTGFLE QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI HSPEVRFNRL LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY LFVIFDFLIG VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK VSKGMEAKVI RWFDYLWTNK KTVDEREILK NLPAKLRAEI AINVHLSTLK KVRIFHDCEA GLLVELVLKL RPQVFSPGDY ICRKGDIGKE MYIIKEGKLA VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI RSLGYSDLFC LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS DGMNSPELAA ADEP
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