About Methionine aminopeptidase 2
Methionine aminopeptidase 2 (METAP2) is a protein
from Homo sapiens identified by UniProt accession
P50579, 478 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Methionine aminopeptidase 2 |
|---|
| UniProt accession | P50579 |
|---|
| Gene | METAP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 478 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (105)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- reticulocyte count · score 0.35
- type 2 diabetes mellitus · score 0.33
- C-reactive protein measurement · score 0.32
- sex hormone-binding globulin measurement · score 0.32
- neuroinflammatory disorder · score 0.32
- reticulocyte measurement · score 0.30
- obesity · score 0.29
- Prader-Willi syndrome · score 0.28
- serum gamma-glutamyl transferase measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50579-F1 | alphafold | PREDICTED | 85.44 | — |
Amino-acid sequence (478 residues)
MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA AGEQEPDKES GASVDEVARQ LERSALEDKE RDEDDEDGDG DGDGATGKKK KKKKKKRGPK VQTDPPSVPI CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDTLLKAV KDATNTGIKC AGIDVRLCDV GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGQYRIHA GKTVPIVKGG EATRMEEGEV YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY
Explore Methionine aminopeptidase 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets