About Methionine aminopeptidase 1
Methionine aminopeptidase 1 (METAP1) is a protein
from Homo sapiens identified by UniProt accession
P53582, 386 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Methionine aminopeptidase 1 |
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| UniProt accession | P53582 |
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| Gene | METAP1 |
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| Organism | Homo sapiens |
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| Length | 386 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- alcohol consumption measurement · score 0.33
- alcohol use disorder measurement · score 0.31
- alcohol dependence measurement · score 0.26
- Intellectual disability · score 0.26
- aspartate aminotransferase measurement · score 0.24
- breast adenocarcinoma · score 0.11
- acute myeloid leukemia · score 0.09
- cystatin C measurement · score 0.09
- myelodysplastic syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53582-F1 | alphafold | PREDICTED | 94.36 | — |
Amino-acid sequence (386 residues)
MAAVETRVCE TDGCSSEAKL QCPTCIKLGI QGSYFCSQEC FKGSWATHKL LHKKAKDEKA KREVSSWTVE GDINTDPWAG YRYTGKLRPH YPLMPTRPVP SYIQRPDYAD HPLGMSESEQ ALKGTSQIKL LSSEDIEGMR LVCRLAREVL DVAAGMIKPG VTTEEIDHAV HLACIARNCY PSPLNYYNFP KSCCTSVNEV ICHGIPDRRP LQEGDIVNVD ITLYRNGYHG DLNETFFVGE VDDGARKLVQ TTYECLMQAI DAVKPGVRYR ELGNIIQKHA QANGFSVVRS YCGHGIHKLF HTAPNVPHYA KNKAVGVMKS GHVFTIEPMI CEGGWQDETW PDGWTAVTRD GKRSAQFEHT LLVTDTGCEI LTRRLDSARP HFMSQF
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