About Polyunsaturated fatty acid lipoxygenase ALOX15
Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15) is a protein
from Homo sapiens identified by UniProt accession
P16050, 662 residues long.
MolForge cross-references it against 0 known binders and
453 disease associations.
Target properties
| Protein name | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| UniProt accession | P16050 |
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| Gene | ALOX15 |
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| Organism | Homo sapiens |
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| Length | 662 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (453)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.65
- eosinophil percentage of leukocytes · score 0.64
- allergic rhinitis · score 0.37
- Nasal Cavity Polyp · score 0.36
- asthma · score 0.36
- Eczematoid dermatitis · score 0.36
- sum of eosinophil and basophil counts · score 0.31
- neutrophil percentage of granulocytes · score 0.30
- eosinophil percentage of granulocytes · score 0.30
- allergic disease · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16050-F1 | alphafold | PREDICTED | 95.34 | — |
Amino-acid sequence (662 residues)
MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGKRLW PARGKETELK VEVPEYLGPL LFVKLRKRHL LKDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGEDP QGLFQKHREE ELEERRKLYR WGNWKDGLIL NMAGAKLYDL PVDERFLEDK RVDFEVSLAK GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV LRRSAHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL VMLKLQPDGK LLPMVIQLQL PRTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI IYRYVEGIVS LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ ARDQVCHFVT MCIFTCTGQH ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSVVENSV AI
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