About Leukotriene B4 receptor 1
Leukotriene B4 receptor 1 (LTB4R) is a protein
from Homo sapiens identified by UniProt accession
Q15722, 352 residues long.
MolForge cross-references it against 0 known binders and
257 disease associations.
Target properties
| Protein name | Leukotriene B4 receptor 1 |
|---|
| UniProt accession | Q15722 |
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| Gene | LTB4R |
|---|
| Organism | Homo sapiens |
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| Length | 352 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (257)
Diseases linked to this target (Open Targets).
- paroxysmal nocturnal hemoglobinuria · score 0.28
- bullous pemphigoid · score 0.26
- thyroid gland adenocarcinoma · score 0.23
- low grade glioma · score 0.12
- chronic obstructive pulmonary disease · score 0.10
- rheumatoid arthritis · score 0.10
- language impairment · score 0.09
- nonpapillary renal cell carcinoma · score 0.09
- neutrophil immunodeficiency syndrome · score 0.08
- osteoarthritis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15722-F1 | alphafold | PREDICTED | 81.41 | — |
Amino-acid sequence (352 residues)
MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN
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