Tolfenamic acid

MUSCULO-SKELETAL SYSTEM

Key facts

Tolfenamic acid is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1976. DrugCentral lists 6 molecular targets, including PTGS2, AKR1C3 and PTGS1.

• Molecular targets: PTGS2, AKR1C3, PTGS1 and MT-CO2 (6 listed in DrugCentral).
• ATC code: M01AG02 (Fenamates).
• Molecular formula: C14H12ClNO2; molecular weight 261.71 g/mol.

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 8.30
Aldo-keto reductase family 1 member C3	AKR1C3	unknown	Ki 8.10
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 6.24
Cytochrome c oxidase subunit 2	MT-CO2	unknown	IC50 5.93
Transthyretin	TTR	unknown	IC50 4.40
Androgen receptor	AR	unknown	IC50 4.33

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1976-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
M01AG02	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Fenamates

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tolfenamic acid is on its molecule page.

• Molecular formula: C₁₄H₁₂ClNO₂
• Molecular weight: 261.71 g/mol
• CAS number: 13710-19-5
• InChIKey: YEZNLOUZAIOMLT-UHFFFAOYSA-N
• PubChem CID: 610479

CC1=C(NC2=C(C=CC=C2)C(O)=O)C=CC=C1Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Tolfenamic acid work?

Its molecular targets in DrugCentral include PTGS2, AKR1C3, PTGS1 and MT-CO2.

When was Tolfenamic acid first approved?

Tolfenamic acid was first approved by the YEAR INTRODUCED in 1976.

What is the chemical formula of Tolfenamic acid?

Tolfenamic acid has the molecular formula C14H12ClNO2 and a molecular weight of 261.71 g/mol.

Sources

• DrugCentral drug card 2698 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL121626 — compound record and bioactivity
• PubChem CID 610479 — chemical identifiers
• DrugBank DB09216 — drug record
• FDA UNII 3G943U18KM — substance identity
• UniProt P35354 (PTGS2) — target protein
• UniProt P42330 (AKR1C3) — target protein
• UniProt P23219 (PTGS1) — target protein
• UniProt P00403 (MT-CO2) — target protein
• UniProt P02766 (TTR) — target protein
• UniProt P10275 (AR) — target protein

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