Fatty acid-binding protein, adipocyte (FABP4)

About Fatty acid-binding protein, adipocyte

Fatty acid-binding protein, adipocyte (FABP4) is a protein from Homo sapiens identified by UniProt accession P15090, 132 residues long. MolForge cross-references it against 0 known binders and 487 disease associations.

Target properties

Protein name	Fatty acid-binding protein, adipocyte
UniProt accession	P15090
Gene	FABP4
Organism	Homo sapiens
Length	132 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (487)

Diseases linked to this target (Open Targets).

fatty acid-binding protein, adipocyte measurement · score 0.30
gestational diabetes · score 0.12
neoplasm · score 0.12
high density lipoprotein cholesterol measurement · score 0.11
type 2 diabetes mellitus · score 0.11
coronary artery disease · score 0.11
breast adenocarcinoma · score 0.11
acute kidney failure · score 0.11
hepatocellular carcinoma · score 0.11
non-alcoholic steatohepatitis · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15090-F1	alphafold	PREDICTED	95.77	—

Amino-acid sequence (132 residues)

MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards