About Nuclear receptor subfamily 4 group A member 2
Nuclear receptor subfamily 4 group A member 2 (NR4A2) is a protein
from Homo sapiens identified by UniProt accession
P43354, 598 residues long.
MolForge cross-references it against 0 known binders and
321 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 4 group A member 2 |
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| UniProt accession | P43354 |
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| Gene | NR4A2 |
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| Organism | Homo sapiens |
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| Length | 598 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (321)
Diseases linked to this target (Open Targets).
- complex neurodevelopmental disorder · score 0.44
- Parkinson disease · score 0.43
- Hereditary late-onset Parkinson disease · score 0.41
- genetic disorder · score 0.41
- age at menarche · score 0.39
- neuroticism measurement · score 0.38
- unipolar depression · score 0.38
- dystonia 5 · score 0.37
- self reported educational attainment · score 0.35
- Neurodevelopmental disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43354-F1 | alphafold | PREDICTED | 65.98 | — |
Amino-acid sequence (598 residues)
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
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