NAD-dependent protein deacylase sirtuin-6 (SIRT6)
Homo sapiens — UniProt Q8N6T7
Data last refreshed: (UniProt release unknown)
Key facts
NAD-dependent protein deacylase sirtuin-6 (SIRT6) is a protein from Homo sapiens identified by UniProt accession Q8N6T7, 355 residues long. MolForge cross-references it against 5 known binders and 394 disease associations.
- UniProt accession: Q8N6T7; gene symbol SIRT6.
- Organism: Homo sapiens.
- Length: 355 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, primary ovarian insufficiency and blood phosphate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NAD-dependent protein deacylase sirtuin-6 |
|---|---|
| UniProt accession | Q8N6T7 |
| Gene | SIRT6 |
| Organism | Homo sapiens |
| Length | 355 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (394)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- primary ovarian insufficiency · score 0.27
- blood phosphate measurement · score 0.18
- lysosomal storage disease · score 0.17
- body height · score 0.13
- neoplasm · score 0.12
- hepatocellular carcinoma · score 0.11
- cancer · score 0.11
- non-small cell lung carcinoma · score 0.11
- Prolonged QT interval · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6T7-F1 | alphafold | PREDICTED | 87.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6T7.
Amino-acid sequence (355 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIRT6?
The strongest Open Targets associations for SIRT6 are neurodegenerative disease, primary ovarian insufficiency, blood phosphate measurement, lysosomal storage disease and body height.
How long is the SIRT6 protein?
The Homo sapiens SIRT6 protein (UniProt Q8N6T7) is 355 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6T7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6T7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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