Free fatty acid receptor 4 (FFAR4)
Homo sapiens — UniProt Q5NUL3
Data last refreshed: (UniProt release unknown)
Key facts
Free fatty acid receptor 4 (FFAR4) is a protein from Homo sapiens identified by UniProt accession Q5NUL3, 361 residues long. MolForge cross-references it against 2 known binders and 228 disease associations.
- UniProt accession: Q5NUL3; gene symbol FFAR4.
- Organism: Homo sapiens.
- Length: 361 amino acids.
- Approved drugs acting on it (DrugCentral): Linoleic Acid and Oleic Acid.
- Top disease associations (Open Targets): progressive retinal dystrophy due to retinol transport defect, microphthalmia, isolated, with coloboma 10 and Bilateral microphthalmos.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Free fatty acid receptor 4 |
|---|---|
| UniProt accession | Q5NUL3 |
| Gene | FFAR4 |
| Organism | Homo sapiens |
| Length | 361 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (228)
Diseases linked to this target (Open Targets).
- progressive retinal dystrophy due to retinol transport defect · score 0.47
- microphthalmia, isolated, with coloboma 10 · score 0.45
- Bilateral microphthalmos · score 0.44
- BMI-adjusted waist-hip ratio · score 0.41
- microphthalmia · score 0.40
- coloboma · score 0.40
- IGF-1 measurement · score 0.39
- waist-hip ratio · score 0.35
- BMI-adjusted waist circumference · score 0.33
- triglyceride measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5NUL3-F1 | alphafold | PREDICTED | 79.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5NUL3.
Amino-acid sequence (361 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target FFAR4?
DrugCentral lists 2 approved drugs whose mechanism of action is FFAR4: Linoleic Acid and Oleic Acid.
Which diseases are associated with FFAR4?
The strongest Open Targets associations for FFAR4 are progressive retinal dystrophy due to retinol transport defect, microphthalmia, isolated, with coloboma 10, Bilateral microphthalmos, BMI-adjusted waist-hip ratio and microphthalmia.
How long is the FFAR4 protein?
The Homo sapiens FFAR4 protein (UniProt Q5NUL3) is 361 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5NUL3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5NUL3 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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