About Peroxisome proliferator-activated receptor delta
Peroxisome proliferator-activated receptor delta (PPARD) is a protein
from Homo sapiens identified by UniProt accession
Q03181, 441 residues long.
MolForge cross-references it against 0 known binders and
526 disease associations.
Target properties
| Protein name | Peroxisome proliferator-activated receptor delta |
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| UniProt accession | Q03181 |
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| Gene | PPARD |
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| Organism | Homo sapiens |
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| Length | 441 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (526)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- primary biliary cirrhosis · score 0.41
- type 2 diabetes mellitus · score 0.38
- lymphocyte count · score 0.38
- cardiovascular disease · score 0.38
- acute myocardial infarction · score 0.37
- heel bone mineral density · score 0.34
- non-alcoholic steatohepatitis · score 0.29
- BMI-adjusted hip circumference · score 0.29
- systolic blood pressure · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q03181-F1 | alphafold | PREDICTED | 82.90 | — |
Amino-acid sequence (441 residues)
MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGD RPGLMNVPRV EAIQDTILRA LEFHLQANHP DAQYLFPKLL QKMADLRQLV TEHAQMMQRI KKTETETSLH PLLQEIYKDM Y
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