About Tyrosine-protein kinase Yes
Tyrosine-protein kinase Yes (YES1) is a protein
from Homo sapiens identified by UniProt accession
P07947, 543 residues long.
MolForge cross-references it against 0 known binders and
211 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Yes |
|---|
| UniProt accession | P07947 |
|---|
| Gene | YES1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 543 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (211)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.58
- cancer · score 0.58
- acute lymphoblastic leukemia · score 0.55
- cutaneous Leishmaniasis · score 0.46
- lymphoid leukemia · score 0.45
- systolic blood pressure · score 0.45
- platelet count · score 0.43
- neoplasm · score 0.42
- multiple myeloma · score 0.40
- serum gamma-glutamyl transferase measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07947-F1 | alphafold | PREDICTED | 81.88 | — |
Amino-acid sequence (543 residues)
MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEPTTVS PCPSSSAKGT AVNFSSLSMT PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY DYEARTTEDL SFKKGERFQI INNTEGDWWE ARSIATGKNG YIPSNYVAPA DSIQAEEWYF GKMGRKDAER LLLNPGNQRG IFLVRESETT KGAYSLSIRD WDEIRGDNVK HYKIRKLDNG GYYITTRAQF DTLQKLVKHY TEHADGLCHK LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MSKGSLLDFL KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGENLVC KIADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LQTELVTKGR VPYPGMVNRE VLEQVERGYR MPCPQGCPES LHELMNLCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG ENL
Explore Tyrosine-protein kinase Yes with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets