About Cytochrome P450 1B1
Cytochrome P450 1B1 (CYP1B1) is a protein
from Homo sapiens identified by UniProt accession
Q16678, 543 residues long.
MolForge cross-references it against 0 known binders and
419 disease associations.
Target properties
| Protein name | Cytochrome P450 1B1 |
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| UniProt accession | Q16678 |
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| Gene | CYP1B1 |
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| Organism | Homo sapiens |
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| Length | 543 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (419)
Diseases linked to this target (Open Targets).
- Juvenile glaucoma · score 0.84
- congenital glaucoma · score 0.71
- Peters anomaly · score 0.65
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.59
- cutaneous melanoma · score 0.49
- anterior segment dysgenesis · score 0.47
- Ocular anterior segment dysgenesis · score 0.47
- open-angle glaucoma · score 0.46
- glaucoma 1, open angle, A · score 0.46
- sunburn · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16678-F1 | alphafold | PREDICTED | 92.21 | — |
Amino-acid sequence (543 residues)
MGTSLSPNDP WPLNPLSIQQ TTLLLLLSVL ATVHVGQRLL RQRRRQLRSA PPGPFAWPLI GNAAAVGQAA HLSFARLARR YGDVFQIRLG SCPIVVLNGE RAIHQALVQQ GSAFADRPAF ASFRVVSGGR SMAFGHYSEH WKVQRRAAHS MMRNFFTRQP RSRQVLEGHV LSEARELVAL LVRGSADGAF LDPRPLTVVA VANVMSAVCF GCRYSHDDPE FRELLSHNEE FGRTVGAGSL VDVMPWLQYF PNPVRTVFRE FEQLNRNFSN FILDKFLRHC ESLRPGAAPR DMMDAFILSA EKKAAGDSHG GGARLDLENV PATITDIFGA SQDTLSTALQ WLLLLFTRYP DVQTRVQAEL DQVVGRDRLP CMGDQPNLPY VLAFLYEAMR FSSFVPVTIP HATTANTSVL GYHIPKDTVV FVNQWSVNHD PLKWPNPENF DPARFLDKDG LINKDLTSRV MIFSVGKRRC IGEELSKMQL FLFISILAHQ CDFRANPNEP AKMNFSYGLT IKPKSFKVNV TLRESMELLD SAVQNLQAKE TCQ
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