Diosmetin

Drug profile

Key facts

Diosmetin is a drug catalogued in DrugCentral. DrugCentral lists 8 molecular targets, including CYP1B1, CYP1A1 and HDAC6.

• Molecular targets: CYP1B1, CYP1A1, HDAC6 and XDH (8 listed in DrugCentral).
• Molecular formula: C16H12O6; molecular weight 300.27 g/mol.

Mechanism & targets

Molecular targets (8)

Target	Gene	Action	Activity
Cytochrome P450 1B1	CYP1B1	unknown	IC50 7.54
Cytochrome P450 1A1	CYP1A1	inhibitor	Ki 7.05
Histone deacetylase 6	HDAC6	unknown	IC50 6.28
Xanthine dehydrogenase/oxidase	XDH	unknown	IC50 6.28
Inositol hexakisphosphate kinase 2	IP6K2	unknown	IC50 6.05
Multidrug resistance-associated protein 1	ABCC1	unknown	IC50 5.52
Inositol polyphosphate multikinase	IPMK	unknown	IC50 5.14
Lysine-specific histone demethylase 1A	KDM1A	unknown	IC50 4.55

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Diosmetin is on its molecule page.

• Molecular formula: C₁₆H₁₂O₆
• Molecular weight: 300.27 g/mol
• CAS number: 520-34-3
• InChIKey: MBNGWHIJMBWFHU-UHFFFAOYSA-N
• PubChem CID: 5281612

COC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O)C=C(O)C=C2O1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Diosmetin work?

Its molecular targets in DrugCentral include CYP1B1, CYP1A1 (inhibitor), HDAC6 and XDH.

What is the chemical formula of Diosmetin?

Diosmetin has the molecular formula C16H12O6 and a molecular weight of 300.27 g/mol.

Sources

• DrugCentral drug card 4601 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL90568 — compound record and bioactivity
• PubChem CID 5281612 — chemical identifiers
• DrugBank DB11259 — drug record
• FDA UNII TWZ37241OT — substance identity
• DailyMed: FDA labels for Diosmetin — current prescribing information (label search)
• UniProt Q16678 (CYP1B1) — target protein
• UniProt P04798 (CYP1A1) — target protein
• UniProt Q9UBN7 (HDAC6) — target protein
• UniProt P47989 (XDH) — target protein
• UniProt Q9UHH9 (IP6K2) — target protein
• UniProt P33527 (ABCC1) — target protein

How this page is built: methodology · editorial policy & corrections.