About Cytochrome P450 1A1
Cytochrome P450 1A1 (CYP1A1) is a protein
from Homo sapiens identified by UniProt accession
P04798, 512 residues long.
MolForge cross-references it against 0 known binders and
582 disease associations.
Target properties
| Protein name | Cytochrome P450 1A1 |
|---|
| UniProt accession | P04798 |
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| Gene | CYP1A1 |
|---|
| Organism | Homo sapiens |
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| Length | 512 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (582)
Diseases linked to this target (Open Targets).
- coffee consumption · score 0.24
- glomerular filtration rate · score 0.23
- cutaneous melanoma · score 0.23
- urinary albumin to creatinine ratio · score 0.22
- urate measurement · score 0.22
- creatinine measurement · score 0.22
- caffeine metabolite measurement · score 0.22
- coffee consumption measurement · score 0.22
- tea consumption measurement · score 0.22
- serum urea measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04798-F1 | alphafold | PREDICTED | 95.50 | — |
Amino-acid sequence (512 residues)
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS
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