About Inositol polyphosphate multikinase
Inositol polyphosphate multikinase (IPMK) is a protein
from Homo sapiens identified by UniProt accession
Q8NFU5, 416 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Inositol polyphosphate multikinase |
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| UniProt accession | Q8NFU5 |
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| Gene | IPMK |
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| Organism | Homo sapiens |
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| Length | 416 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- inflammatory bowel disease · score 0.38
- Crohn's disease · score 0.38
- hereditary neuroendocrine tumor of small intestine · score 0.37
- monocyte count · score 0.36
- psoriasis · score 0.33
- platelet component distribution width · score 0.23
- monocyte percentage of leukocytes · score 0.23
- cleft lip · score 0.08
- sex interaction measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NFU5-F1 | alphafold | PREDICTED | 73.76 | — |
Amino-acid sequence (416 residues)
MATEPPSPLR VEAPGPPEMR TSPAIESTPE GTPQPAGGRL RFLNGCVPLS HQVAGHMYGK DKVGILQHPD GTVLKQLQPP PRGPRELEFY NMVYAADCFD GVLLELRKYL PKYYGIWSPP TAPNDLYLKL EDVTHKFNKP CIMDVKIGQK SYDPFASSEK IQQQVSKYPL MEEIGFLVLG MRVYHVHSDS YETENQHYGR SLTKETIKDG VSRFFHNGYC LRKDAVAASI QKIEKILQWF ENQKQLNFYA SSLLFVYEGS SQPTTTKLND RTLAEKFLSK GQLSDTEVLE YNNNFHVLSS TANGKIESSV GKSLSKMYAR HRKIYTKKHH SQTSLKVENL EQDNGWKSMS QEHLNGNVLS QLEKVFYHLP TGCQEIAEVE VRMIDFAHVF PSNTIDEGYV YGLKHLISVL RSILDN
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