Inositol hexakisphosphate kinase 2 (IP6K2)
Homo sapiens — UniProt Q9UHH9
Data last refreshed: (UniProt release unknown)
Key facts
Inositol hexakisphosphate kinase 2 (IP6K2) is a protein from Homo sapiens identified by UniProt accession Q9UHH9, 426 residues long. MolForge cross-references it against 2 known binders and 98 disease associations.
- UniProt accession: Q9UHH9; gene symbol IP6K2.
- Organism: Homo sapiens.
- Length: 426 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and neuroimaging measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inositol hexakisphosphate kinase 2 |
|---|---|
| UniProt accession | Q9UHH9 |
| Gene | IP6K2 |
| Organism | Homo sapiens |
| Length | 426 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- neuroinflammatory disorder · score 0.37
- neuroimaging measurement · score 0.26
- hair colour measurement · score 0.25
- brain measurement · score 0.25
- high density lipoprotein cholesterol measurement · score 0.24
- body height · score 0.24
- chronotype measurement · score 0.23
- smoking status measurement · score 0.21
- age at first sexual intercourse measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHH9-F1 | alphafold | PREDICTED | 76.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHH9.
Amino-acid sequence (426 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IP6K2?
The strongest Open Targets associations for IP6K2 are neurodegenerative disease, neuroinflammatory disorder, neuroimaging measurement, hair colour measurement and brain measurement.
How long is the IP6K2 protein?
The Homo sapiens IP6K2 protein (UniProt Q9UHH9) is 426 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHH9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHH9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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