Serine/threonine-protein kinase pim-1 (PIM1)

About Serine/threonine-protein kinase pim-1

Serine/threonine-protein kinase pim-1 (PIM1) is a protein from Homo sapiens identified by UniProt accession P11309, 313 residues long. MolForge cross-references it against 0 known binders and 335 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase pim-1
UniProt accession	P11309
Gene	PIM1
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (335)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
diffuse large B-cell lymphoma · score 0.47
mean corpuscular volume · score 0.46
multiple myeloma · score 0.45
lymphoid neoplasm · score 0.43
mean corpuscular hemoglobin · score 0.42
mean reticulocyte volume · score 0.39
Central Nervous System Lymphoma · score 0.38
Red cell distribution width · score 0.38
erythrocyte count · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11309-F1	alphafold	PREDICTED	89.43	—

Amino-acid sequence (313 residues)

MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG SVYSGIRVSD NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSGF SGVIRLLDWF ERPDSFVLIL ERPEPVQDLF DFITERGALQ EELARSFFWQ VLEAVRHCHN CGVLHRDIKD ENILIDLNRG ELKLIDFGSG ALLKDTVYTD FDGTRVYSPP EWIRYHRYHG RSAAVWSLGI LLYDMVCGDI PFEHDEEIIR GQVFFRQRVS SECQHLIRWC LALRPSDRPT FEEIQNHPWM QDVLLPQETA EIHLHSLSPG PSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards