Cyclin-dependent kinase 1 (CDK1)

About Cyclin-dependent kinase 1

Cyclin-dependent kinase 1 (CDK1) is a protein from Homo sapiens identified by UniProt accession P06493, 297 residues long. MolForge cross-references it against 0 known binders and 462 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 1
UniProt accession	P06493
Gene	CDK1
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (462)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
Parkinson disease · score 0.51
Alzheimer disease · score 0.51
lysosomal storage disease · score 0.51
multiple sclerosis · score 0.51
neuroinflammatory disorder · score 0.35
lung adenocarcinoma · score 0.31
chronic lymphocytic leukemia · score 0.30
ovarian cancer · score 0.29
small cell lung carcinoma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P06493-F1	alphafold	PREDICTED	89.34	—

Amino-acid sequence (297 residues)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT FPKWKPGSLA SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards