About Prothrombin
Prothrombin (F2) is a protein
from Homo sapiens identified by UniProt accession
P00734, 622 residues long.
MolForge cross-references it against 0 known binders and
1,027 disease associations.
Target properties
| Protein name | Prothrombin |
|---|
| UniProt accession | P00734 |
|---|
| Gene | F2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 622 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1027)
Diseases linked to this target (Open Targets).
- congenital prothrombin deficiency · score 0.80
- Congenital factor II deficiency · score 0.77
- thrombophilia due to thrombin defect · score 0.73
- stroke · score 0.68
- prothrombin deficiency · score 0.64
- venous thromboembolism · score 0.64
- atrial fibrillation · score 0.61
- Thrombocytopenia · score 0.60
- coronary artery disease · score 0.59
- deep vein thrombosis · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00734-F1 | alphafold | PREDICTED | 83.92 | — |
Amino-acid sequence (622 residues)
MAHVRGLQLP GCLALAALCS LVHSQHVFLA PQQARSLLQR VRRANTFLEE VRKGNLEREC VEETCSYEEA FEALESSTAT DVFWAKYTAC ETARTPRDKL AACLEGNCAE GLGTNYRGHV NITRSGIECQ LWRSRYPHKP EINSTTHPGA DLQENFCRNP DSSTTGPWCY TTDPTVRRQE CSIPVCGQDQ VTVAMTPRSE GSSVNLSPPL EQCVPDRGQQ YQGRLAVTTH GLPCLAWASA QAKALSKHQD FNSAVQLVEN FCRNPDGDEE GVWCYVAGKP GDFGYCDLNY CEEAVEEETG DGLDEDSDRA IEGRTATSEY QTFFNPRTFG SGEADCGLRP LFEKKSLEDK TERELLESYI DGRIVEGSDA EIGMSPWQVM LFRKSPQELL CGASLISDRW VLTAAHCLLY PPWDKNFTEN DLLVRIGKHS RTRYERNIEK ISMLEKIYIH PRYNWRENLD RDIALMKLKK PVAFSDYIHP VCLPDRETAA SLLQAGYKGR VTGWGNLKET WTANVGKGQP SVLQVVNLPI VERPVCKDST RIRITDNMFC AGYKPDEGKR GDACEGDSGG PFVMKSPFNN RWYQMGIVSW GEGCDRDGKY GFYTHVFRLK KWIQKVIDQF GE
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