Betrixaban

Factor Xa Inhibitor — BLOOD AND BLOOD FORMING ORGANS

Key facts

Betrixaban is an ofm drug in the Factor Xa Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 2017. Its mechanism of action is classified as Factor Xa Inhibitors. DrugCentral lists 3 molecular targets, including F10, KCNH2 and F2. Recorded indications include At risk of venous thromboembolus.

• Approval status: ofm (first approved 2017 by the FDA).
• Drug class: Factor Xa Inhibitor.
• Mechanism of action: Factor Xa Inhibitors.
• Molecular targets: F10, KCNH2 and F2 (3 listed in DrugCentral).
• Indications: At risk of venous thromboembolus.
• ATC code: B01AF04 (Direct factor Xa inhibitors).
• Molecular formula: C23H22ClN5O3; molecular weight 451.91 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• At risk of venous thromboembolus

Mechanism & targets

• Mechanism of action (MoA): Factor Xa Inhibitors
• Established pharmacologic class: Factor Xa Inhibitor

Molecular targets (3)

Target	Gene	Action	Activity
Coagulation factor X	F10	inhibitor	IC50 8.82
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	Ki 5.75
Prothrombin	F2	unknown	IC50 4.75

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2017-06-23	FDA	—	PORTOLA PHARMA INC

ATC classification

ATC code	Therapeutic hierarchy
B01AF04	BLOOD AND BLOOD FORMING ORGANS › ANTITHROMBOTIC AGENTS › ANTITHROMBOTIC AGENTS › Direct factor Xa inhibitors

Chemical structure

• Molecular formula: C₂₃H₂₂ClN₅O₃
• Molecular weight: 451.91 g/mol
• CAS number: 330942-05-7
• InChIKey: XHOLNRLADUSQLD-UHFFFAOYSA-N
• PubChem CID: 10275777

COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC1=CC=C(Cl)C=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Betrixaban used for?

DrugCentral lists the following indications for Betrixaban: At risk of venous thromboembolus.

How does Betrixaban work?

Betrixaban is classified as Factor Xa Inhibitors; its molecular targets in DrugCentral include F10 (inhibitor), KCNH2 and F2.

When was Betrixaban first approved?

Betrixaban was first approved by the FDA in 2017.

What drug class does Betrixaban belong to?

Betrixaban is in the Factor Xa Inhibitor class.

What is the chemical formula of Betrixaban?

Betrixaban has the molecular formula C23H22ClN5O3 and a molecular weight of 451.91 g/mol.

Sources

• DrugCentral drug card 5241 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL512351 — compound record and bioactivity
• PubChem CID 10275777 — chemical identifiers
• DrugBank DB12364 — drug record
• FDA UNII 74RWP7W0J9 — substance identity
• DailyMed: FDA labels for Betrixaban — current prescribing information (label search)
• UniProt P00742 (F10) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt P00734 (F2) — target protein

How this page is built: methodology · editorial policy & corrections.