Coagulation factor X (F10)

About Coagulation factor X

Coagulation factor X (F10) is a protein from Homo sapiens identified by UniProt accession P00742, 488 residues long. MolForge cross-references it against 0 known binders and 481 disease associations.

Target properties

Protein name	Coagulation factor X
UniProt accession	P00742
Gene	F10
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (481)

Diseases linked to this target (Open Targets).

congenital factor X deficiency · score 0.81
factor X deficiency · score 0.71
venous thromboembolism · score 0.66
deep vein thrombosis · score 0.65
atrial fibrillation · score 0.61
COVID-19 · score 0.58
stroke · score 0.58
hemophilia A · score 0.58
pulmonary embolism · score 0.58
acute coronary syndrome · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00742-F1	alphafold	PREDICTED	80.23	—

Amino-acid sequence (488 residues)

MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK GHLERECMEE TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK CKDGLGEYTC TCLEGFEGKN CELFTRKLCS LDNGDCDQFC HEEQNSVVCS CARGYTLADN GKACIPTGPY PCGKQTLERR KRSVAQATSS SGEAPDSITW KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE CKDGECPWQA LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKVRVGD RNTEQEEGGE AVHEVEVVIK HNRFTKETYD FDIAVLRLKT PITFRMNVAP ACLPERDWAE STLMTQKTGI VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ NMFCAGYDTK QEDACQGDSG GPHVTRFKDT YFVTGIVSWG EGCARKGKYG IYTKVTAFLK WIDRSMKTRG LPKAKSHAPE VITSSPLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards