Gabexate

Drug profile

Key facts

Gabexate is a drug catalogued in DrugCentral. DrugCentral lists 14 molecular targets, including TPSAB1, TMPRSS2 and HPN.

• Molecular targets: TPSAB1, TMPRSS2, HPN and PLAU (14 listed in DrugCentral).
• Molecular formula: C16H23N3O4; molecular weight 321.38 g/mol.

Mechanism & targets

Molecular targets (14)

Target	Gene	Action	Activity
Tryptase alpha/beta-1	TPSAB1	inhibitor	IC50 8.47
Transmembrane protease serine 2	TMPRSS2	unknown	IC50 6.89
Serine protease hepsin	HPN	unknown	IC50 6.42
Urokinase-type plasminogen activator	PLAU	unknown	IC50 6.37
Multidrug and toxin extrusion protein 1	SLC47A1	unknown	IC50 6.30
Prothrombin	F2	unknown	IC50 6.16
Solute carrier family 22 member 2	SLC22A2	unknown	IC50 6.05
Plasma kallikrein	KLKB1	unknown	IC50 5.87
Plasminogen	PLG	unknown	IC50 5.81
Coagulation factor XII	F12	unknown	Ki 5.54
Coagulation factor X	F10	unknown	IC50 5.34
Multidrug and toxin extrusion protein 2	SLC47A2	unknown	IC50 4.97
Tissue-type plasminogen activator	PLAT	unknown	IC50 4.81
Membrane primary amine oxidase	Aoc3	unknown	Ki 4.57

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Disseminated intravascular coagulation	47.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Gabexate is on its molecule page.

• Molecular formula: C₁₆H₂₃N₃O₄
• Molecular weight: 321.38 g/mol
• CAS number: 39492-01-8
• InChIKey: YKGYIDJEEQRWQH-UHFFFAOYSA-N
• PubChem CID: 3447

CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Gabexate work?

Its molecular targets in DrugCentral include TPSAB1 (inhibitor), TMPRSS2, HPN and PLAU.

What is the chemical formula of Gabexate?

Gabexate has the molecular formula C16H23N3O4 and a molecular weight of 321.38 g/mol.

Sources

• DrugCentral drug card 3257 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL87563 — compound record and bioactivity
• PubChem CID 3447 — chemical identifiers
• DrugBank DB12831 — drug record
• FDA UNII 4V7M9137X9 — substance identity
• UniProt Q15661 (TPSAB1) — target protein
• UniProt O15393 (TMPRSS2) — target protein
• UniProt P05981 (HPN) — target protein
• UniProt P00749 (PLAU) — target protein
• UniProt Q96FL8 (SLC47A1) — target protein
• UniProt P00734 (F2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.