About Tissue-type plasminogen activator
Tissue-type plasminogen activator (PLAT) is a protein
from Homo sapiens identified by UniProt accession
P00750, 562 residues long.
MolForge cross-references it against 0 known binders and
1,026 disease associations.
Target properties
| Protein name | Tissue-type plasminogen activator |
|---|
| UniProt accession | P00750 |
|---|
| Gene | PLAT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 562 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1026)
Diseases linked to this target (Open Targets).
- pulmonary embolism · score 0.60
- stroke · score 0.60
- myocardial infarction · score 0.59
- hemorrhage · score 0.58
- Ischemic stroke · score 0.58
- acute myocardial infarction · score 0.56
- thrombotic disease · score 0.54
- ST Elevation Myocardial Infarction · score 0.53
- Recurrent thrombophlebitis · score 0.50
- heart failure · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00750-F1 | alphafold | PREDICTED | 80.95 | — |
Amino-acid sequence (562 residues)
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK DVPGVYTKVT NYLDWIRDNM RP
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