Serine protease hepsin (HPN)

About Serine protease hepsin

Serine protease hepsin (HPN) is a protein from Homo sapiens identified by UniProt accession P05981, 417 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.

Target properties

Protein name	Serine protease hepsin
UniProt accession	P05981
Gene	HPN
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (157)

Diseases linked to this target (Open Targets).

serum albumin measurement · score 0.46
sex hormone-binding globulin measurement · score 0.41
triglyceride measurement · score 0.39
C-reactive protein measurement · score 0.38
calcium measurement · score 0.37
testosterone measurement · score 0.37
total blood protein measurement · score 0.37
urinary albumin to creatinine ratio · score 0.35
alkaline phosphatase measurement · score 0.34
platelet count · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05981-F1	alphafold	PREDICTED	91.12	—

Amino-acid sequence (417 residues)

MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards