Camostat

BLOOD AND BLOOD FORMING ORGANS

Key facts

Camostat is a drug catalogued in DrugCentral. DrugCentral lists 11 molecular targets, including HPN, PRSS1 and TMPRSS2. Recorded indications include Gastro-esophageal reflux disease with esophagitis.

• Molecular targets: HPN, PRSS1, TMPRSS2 and KLK1 (11 listed in DrugCentral).
• Indications: Gastro-esophageal reflux disease with esophagitis.
• ATC code: B02AB04 (Proteinase inhibitors).
• Molecular formula: C20H22N4O5; molecular weight 398.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Gastro-esophageal reflux disease with esophagitis

Mechanism & targets

Molecular targets (11)

Target	Gene	Action	Activity
Serine protease hepsin	HPN	unknown	IC50 7.54
Trypsin-1	PRSS1	inhibitor	IC50 7.30
Transmembrane protease serine 2	TMPRSS2	inhibitor	IC50 6.00
Kallikrein-1	KLK1	unknown	IC50 5.83
Plasminogen	Plg	unknown	IC50 5.58
Multidrug and toxin extrusion protein 1	SLC47A1	unknown	IC50 5.54
Cathepsin L1	CTSL	unknown	IC50 5.00
Multidrug and toxin extrusion protein 2	SLC47A2	unknown	IC50 4.90
Solute carrier family 22 member 2	SLC22A2	unknown	IC50 4.78
Prothrombin	F2	unknown	IC50 4.50
Hepatocyte growth factor activator	HGFAC	unknown	IC50 4.49

ATC classification

ATC code	Therapeutic hierarchy
B02AB04	BLOOD AND BLOOD FORMING ORGANS › ANTIHEMORRHAGICS › ANTIFIBRINOLYTICS › Proteinase inhibitors

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Platelet count decreased	39.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Camostat is on its molecule page.

• Molecular formula: C₂₀H₂₂N₄O₅
• Molecular weight: 398.42 g/mol
• CAS number: 59721-28-7
• InChIKey: XASIMHXSUQUHLV-UHFFFAOYSA-N
• PubChem CID: 2536

CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Camostat used for?

DrugCentral lists the following indications for Camostat: Gastro-esophageal reflux disease with esophagitis.

How does Camostat work?

Its molecular targets in DrugCentral include HPN, PRSS1 (inhibitor), TMPRSS2 (inhibitor) and KLK1.

What is the chemical formula of Camostat?

Camostat has the molecular formula C20H22N4O5 and a molecular weight of 398.42 g/mol.

Sources

• DrugCentral drug card 471 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL590799 — compound record and bioactivity
• PubChem CID 2536 — chemical identifiers
• DrugBank DB13729 — drug record
• FDA UNII 0FD207WKDU — substance identity
• UniProt P05981 (HPN) — target protein
• UniProt P07477 (PRSS1) — target protein
• UniProt O15393 (TMPRSS2) — target protein
• UniProt P06870 (KLK1) — target protein
• UniProt Q96FL8 (SLC47A1) — target protein
• UniProt P07711 (CTSL) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.