Aprotinin

Antifibrinolytic Agent — BLOOD AND BLOOD FORMING ORGANS

Key facts

Aprotinin is a drug in the Antifibrinolytic Agent class catalogued in DrugCentral. It was first approved by the FDA in 1993. DrugCentral lists 2 molecular targets, including PLG and KLKB1. Recorded indications include Hemorrhage.

• Drug class: Antifibrinolytic Agent.
• Molecular targets: PLG and KLKB1 (2 listed in DrugCentral).
• Indications: Hemorrhage.
• ATC code: B02AB01 (Proteinase inhibitors).
• Molecular formula: C284H432N84O79S7; molecular weight 6511.51 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hemorrhage

Mechanism & targets

• Established pharmacologic class: Antifibrinolytic Agent

Molecular targets (2)

Target	Gene	Action	Activity
Plasminogen	PLG	inhibitor	IC50 6.80
Plasma kallikrein	KLKB1	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1993-12-29	FDA	—	BAYER HLTHCARE

ATC classification

ATC code	Therapeutic hierarchy
B02AB01	BLOOD AND BLOOD FORMING ORGANS › ANTIHEMORRHAGICS › ANTIFIBRINOLYTICS › Proteinase inhibitors

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Product use in unapproved indication	281.4
Off label use	158.8

Chemical structure

• Molecular formula: C₂₈₄H₄₃₂N₈₄O₇₉S₇
• Molecular weight: 6511.51 g/mol
• CAS number: 9087-70-1
• InChIKey: —
• PubChem CID: 16130295

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Aprotinin used for?

DrugCentral lists the following indications for Aprotinin: Hemorrhage.

How does Aprotinin work?

Its molecular targets in DrugCentral include PLG (inhibitor) and KLKB1 (inhibitor).

When was Aprotinin first approved?

Aprotinin was first approved by the FDA in 1993.

What drug class does Aprotinin belong to?

Aprotinin is in the Antifibrinolytic Agent class.

What is the chemical formula of Aprotinin?

Aprotinin has the molecular formula C284H432N84O79S7 and a molecular weight of 6511.51 g/mol.

Sources

• DrugCentral drug card 4839 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201619 — compound record and bioactivity
• PubChem CID 16130295 — chemical identifiers
• DrugBank DB06692 — drug record
• FDA UNII 04XPW8C0FL — substance identity
• DailyMed: FDA labels for Aprotinin — current prescribing information (label search)
• UniProt P00747 (PLG) — target protein
• UniProt P03952 (KLKB1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.