About Hepatocyte growth factor activator serine protease
Hepatocyte growth factor activator serine protease (HGFAC) is a protein
from Homo sapiens identified by UniProt accession
Q04756, 655 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Hepatocyte growth factor activator serine protease |
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| UniProt accession | Q04756 |
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| Gene | HGFAC |
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| Organism | Homo sapiens |
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| Length | 655 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (177)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.59
- platelet count · score 0.52
- low density lipoprotein cholesterol measurement · score 0.51
- serum albumin measurement · score 0.51
- calcium measurement · score 0.50
- testosterone measurement · score 0.50
- blood protein measurement · score 0.50
- serum gamma-glutamyl transferase measurement · score 0.50
- triglyceride measurement · score 0.50
- total cholesterol measurement · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q04756-F1 | alphafold | PREDICTED | 75.30 | — |
Amino-acid sequence (655 residues)
MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE YCRLEACESL TRVQLSPDLL ATLPEPASPG RQACGRRHKK RTFLRPRIIG GSSSLPGSHP WLAAIYIGDS FCAGSLVHTC WVVSAAHCFS HSPPRDSVSV VLGQHFFNRT TDVTQTFGIE KYIPYTLYSV FNPSDHDLVL IRLKKKGDRC ATRSQFVQPI CLPEPGSTFP AGHKCQIAGW GHLDENVSGY SSSLREALVP LVADHKCSSP EVYGADISPN MLCAGYFDCK SDACQGDSGG PLACEKNGVA YLYGIISWGD GCGRLHKPGV YTRVANYVDW INDRIRPPRR LVAPS
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