Procathepsin L (CTSL)

About Procathepsin L

Procathepsin L (CTSL) is a protein from Homo sapiens identified by UniProt accession P07711, 333 residues long. MolForge cross-references it against 0 known binders and 829 disease associations.

Target properties

Protein name	Procathepsin L
UniProt accession	P07711
Gene	CTSL
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (829)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
COVID-19 · score 0.39
Parkinson disease · score 0.37
severe acute respiratory syndrome · score 0.37
lysosomal storage disease · score 0.37
multiple sclerosis · score 0.37
Alzheimer disease · score 0.37
cathepsin L1 measurement · score 0.32
gut microbiome measurement · score 0.22
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07711-F1	alphafold	PREDICTED	93.52	—

Amino-acid sequence (333 residues)

MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNMKMIE LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards