About Kallikrein-1
Kallikrein-1 (KLK1) is a protein
from Homo sapiens identified by UniProt accession
P06870, 262 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | Kallikrein-1 |
|---|
| UniProt accession | P06870 |
|---|
| Gene | KLK1 |
|---|
| Organism | Homo sapiens |
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| Length | 262 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (192)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.30
- cystatin C measurement · score 0.25
- cutaneous melanoma · score 0.18
- kallikrein, decreased urinary activity of · score 0.18
- lung adenocarcinoma · score 0.11
- acute kidney failure · score 0.08
- acute myocardial infarction · score 0.07
- chronic obstructive pulmonary disease · score 0.06
- Barrett's esophagus · score 0.05
- pulmonary arterial hypertension · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06870-F1 | alphafold | PREDICTED | 91.60 | — |
Amino-acid sequence (262 residues)
MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CEQHSQPWQA ALYHFSTFQC GGILVHRQWV LTAAHCISDN YQLWLGRHNL FDDENTAQFV HVSESFPHPG FNMSLLENHT RQADEDYSHD LMLLRLTEPA DTITDAVKVV ELPTEEPEVG STCLASGWGS IEPENFSFPD DLQCVDLKIL PNDECKKAHV QKVTDFMLCV GHLEGGKDTC VGDSGGPLMC DGVLQGVTSW GYVPCGTPNK PSVAVRVLSY VKWIEDTIAE NS
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