About Transmembrane protease serine 2
Transmembrane protease serine 2 (TMPRSS2) is a protein
from Homo sapiens identified by UniProt accession
O15393, 492 residues long.
MolForge cross-references it against 0 known binders and
478 disease associations.
Target properties
| Protein name | Transmembrane protease serine 2 |
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| UniProt accession | O15393 |
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| Gene | TMPRSS2 |
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| Organism | Homo sapiens |
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| Length | 492 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (478)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.56
- COVID-19 · score 0.52
- prostate adenocarcinoma · score 0.44
- serum gamma-glutamyl transferase measurement · score 0.42
- benign prostatic hyperplasia · score 0.38
- severe acute respiratory syndrome · score 0.38
- Prostate Small Cell Carcinoma · score 0.37
- prostate intraepithelial neoplasia · score 0.37
- Acinar Prostate Adenocarcinoma, Foamy Gland Variant · score 0.37
- Grade III Prostatic Intraepithelial Neoplasia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15393-F1 | alphafold | PREDICTED | 79.36 | — |
Amino-acid sequence (492 residues)
MALNSGSPPA IGPYYENHGY QPENPYPAQP TVVPTVYEVH PAQYYPSPVP QYAPRVLTQA SNPVVCTQPK SPSGTVCTSK TKKALCITLT LGTFLVGAAL AAGLLWKFMG SKCSNSGIEC DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF TDWIYRQMRA DG
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