Debrisoquine
CARDIOVASCULAR SYSTEM
Also known as: debrisoquin, debrisoquin sulfate, isocaramidine
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Debrisoquine is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1965. DrugCentral lists 3 molecular targets, including TMPRSS2, MAOB and MAOA.
- Molecular targets: TMPRSS2, MAOB and MAOA (3 listed in DrugCentral).
- ATC code: C02CC04 (Guanidine derivatives).
- Molecular formula: C10H13N3; molecular weight 175.24 g/mol.
Mechanism & targets
Molecular targets (3)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Transmembrane protease serine 2 | TMPRSS2 | unknown | IC50 4.64 |
| Amine oxidase [flavin-containing] B | MAOB | unknown | — |
| Amine oxidase [flavin-containing] A | MAOA | unknown | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1965-01-01 | YEAR INTRODUCED | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C02CC04 | CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING › Guanidine derivatives |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Debrisoquine is on its molecule page.
| Molecular formula | C10H13N3 |
|---|---|
| Molecular weight | 175.24 g/mol |
| CAS number | 1131-64-2 |
| InChIKey | JWPGJSVJDAJRLW-UHFFFAOYSA-N |
| PubChem CID | 2966 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
How does Debrisoquine work?
Its molecular targets in DrugCentral include TMPRSS2, MAOB and MAOA.
When was Debrisoquine first approved?
Debrisoquine was first approved by the YEAR INTRODUCED in 1965.
What is the chemical formula of Debrisoquine?
Debrisoquine has the molecular formula C10H13N3 and a molecular weight of 175.24 g/mol.
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Sources
- DrugCentral drug card 788 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1593558 — compound record and bioactivity
- PubChem CID 2966 — chemical identifiers
- DrugBank DB04840 — drug record
- FDA UNII X31CDK040E — substance identity
- UniProt O15393 (TMPRSS2) — target protein
- UniProt P27338 (MAOB) — target protein
- UniProt P21397 (MAOA) — target protein
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