Serine protease 1 (PRSS1)

About Serine protease 1

Serine protease 1 (PRSS1) is a protein from Homo sapiens identified by UniProt accession P07477, 247 residues long. MolForge cross-references it against 0 known binders and 182 disease associations.

Target properties

Protein name	Serine protease 1
UniProt accession	P07477
Gene	PRSS1
Organism	Homo sapiens
Length	247 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (182)

Diseases linked to this target (Open Targets).

hereditary chronic pancreatitis · score 0.81
chronic pancreatitis · score 0.71
trypsinogen deficiency · score 0.37
Hypocalcemic vitamin D-resistant rickets · score 0.34
neuroinflammatory disorder · score 0.34
alcoholic pancreatitis · score 0.28
neurodegenerative disease · score 0.27
pancreatitis · score 0.21
Malignant Pancreatic Neoplasm · score 0.18
lung adenocarcinoma · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07477-F1	alphafold	PREDICTED	92.06	—

Amino-acid sequence (247 residues)

MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK NTIAANS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards