Hexamidine

DERMATOLOGICALS

Key facts

Hexamidine is a drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including F2, ST14 and PRSS1. Recorded indications include Acanthamoeba keratitis.

• Molecular targets: F2, ST14, PRSS1 and PLAU (5 listed in DrugCentral).
• Indications: Acanthamoeba keratitis.
• ATC code: D08AC04 (Biguanides and amidines).
• Molecular formula: C20H26N4O2; molecular weight 354.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Acanthamoeba keratitis

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Prothrombin	F2	unknown	Ki 6.65
Suppressor of tumorigenicity 14 protein	ST14	unknown	Ki 6.03
Trypsin-1	PRSS1	unknown	Ki 5.57
Urokinase-type plasminogen activator	PLAU	unknown	Ki 4.84
Protein arginine N-methyltransferase 1	PRMT1	unknown	IC50 4.28

ATC classification

ATC code	Therapeutic hierarchy
D08AC04	DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Biguanides and amidines
R01AX07	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Other nasal preparations
R02AA18	RESPIRATORY SYSTEM › THROAT PREPARATIONS › THROAT PREPARATIONS › Antiseptics
S01AX08	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Other antiinfectives
S03AA05	SENSORY ORGANS › OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS › ANTIINFECTIVES › Antiinfectives

Chemical structure

• Molecular formula: C₂₀H₂₆N₄O₂
• Molecular weight: 354.45 g/mol
• CAS number: —
• InChIKey: OQLKNTOKMBVBKV-UHFFFAOYSA-N
• PubChem CID: 65130

NC(=N)C1=CC=C(OCCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Hexamidine used for?

DrugCentral lists the following indications for Hexamidine: Acanthamoeba keratitis.

How does Hexamidine work?

Its molecular targets in DrugCentral include F2, ST14, PRSS1 and PLAU.

What is the chemical formula of Hexamidine?

Hexamidine has the molecular formula C20H26N4O2 and a molecular weight of 354.45 g/mol.

Sources

• DrugCentral drug card 3275 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL25105 — compound record and bioactivity
• PubChem CID 65130 — chemical identifiers
• DrugBank DB03808 — drug record
• FDA UNII 3483C2H13H — substance identity
• UniProt P00734 (F2) — target protein
• UniProt Q9Y5Y6 (ST14) — target protein
• UniProt P07477 (PRSS1) — target protein
• UniProt P00749 (PLAU) — target protein
• UniProt Q99873 (PRMT1) — target protein

How this page is built: methodology · editorial policy & corrections.