Suppressor of tumorigenicity 14 protein (ST14)
Homo sapiens — UniProt Q9Y5Y6
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of tumorigenicity 14 protein (ST14) is a protein from Homo sapiens identified by UniProt accession Q9Y5Y6, 855 residues long. MolForge cross-references it against 5 known binders and 398 disease associations.
- UniProt accession: Q9Y5Y6; gene symbol ST14.
- Organism: Homo sapiens.
- Length: 855 amino acids.
- Top disease associations (Open Targets): Ichthyosis-hypotrichosis syndrome, autosomal recessive congenital ichthyosis 11 and viral load.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of tumorigenicity 14 protein |
|---|---|
| UniProt accession | Q9Y5Y6 |
| Gene | ST14 |
| Organism | Homo sapiens |
| Length | 855 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (398)
Diseases linked to this target (Open Targets).
- Ichthyosis-hypotrichosis syndrome · score 0.75
- autosomal recessive congenital ichthyosis 11 · score 0.71
- viral load · score 0.34
- creatinine measurement · score 0.32
- metabolite measurement · score 0.28
- glioblastoma multiforme · score 0.23
- ovarian cancer · score 0.20
- head and neck squamous cell carcinoma · score 0.19
- genetic disorder · score 0.19
- pancreatic adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Y6-F1 | alphafold | PREDICTED | 80.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Y6.
Amino-acid sequence (855 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ST14?
The strongest Open Targets associations for ST14 are Ichthyosis-hypotrichosis syndrome, autosomal recessive congenital ichthyosis 11, viral load, creatinine measurement and metabolite measurement.
How long is the ST14 protein?
The Homo sapiens ST14 protein (UniProt Q9Y5Y6) is 855 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Y6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Y6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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