Protein arginine N-methyltransferase 1 (PRMT1)

About Protein arginine N-methyltransferase 1

Protein arginine N-methyltransferase 1 (PRMT1) is a protein from Homo sapiens identified by UniProt accession Q99873, 371 residues long. MolForge cross-references it against 0 known binders and 242 disease associations.

Target properties

Protein name	Protein arginine N-methyltransferase 1
UniProt accession	Q99873
Gene	PRMT1
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (242)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
COVID-19 · score 0.37
breast adenocarcinoma · score 0.27
endometrial cancer · score 0.25
gastric adenocarcinoma · score 0.24
body height · score 0.24
ovarian cancer · score 0.23
prostate adenocarcinoma · score 0.13
neoplasm · score 0.11
hepatocellular carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99873-F1	alphafold	PREDICTED	88.34	—

Amino-acid sequence (371 residues)

MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC ELSCSTDYRM R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards