Urokinase-type plasminogen activator (PLAU)

About Urokinase-type plasminogen activator

Urokinase-type plasminogen activator (PLAU) is a protein from Homo sapiens identified by UniProt accession P00749, 431 residues long. MolForge cross-references it against 0 known binders and 617 disease associations.

Target properties

Protein name	Urokinase-type plasminogen activator
UniProt accession	P00749
Gene	PLAU
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (617)

Diseases linked to this target (Open Targets).

Quebec platelet disorder · score 0.66
blood protein measurement · score 0.42
pulmonary embolism · score 0.39
coronary artery disease · score 0.38
myocardial infarction · score 0.37
subarachnoid hemorrhage · score 0.37
Recurrent thrombophlebitis · score 0.37
Crohn's disease · score 0.35
inflammatory bowel disease · score 0.34
stroke · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P00749-F1	alphafold	PREDICTED	82.12	—

Amino-acid sequence (431 residues)

MRALLARLLL CVLVVSDSKG SNELHQVPSN CDCLNGGTCV SNKYFSNIHW CNCPKKFGGQ HCEIDKSKTC YEGNGHFYRG KASTDTMGRP CLPWNSATVL QQTYHAHRSD ALQLGLGKHN YCRNPDNRRR PWCYVQVGLK LLVQECMVHD CADGKKPSSP PEELKFQCGQ KTLRPRFKII GGEFTTIENQ PWFAAIYRRH RGGSVTYVCG GSLISPCWVI SATHCFIDYP KKEDYIVYLG RSRLNSNTQG EMKFEVENLI LHKDYSADTL AHHNDIALLK IRSKEGRCAQ PSRTIQTICL PSMYNDPQFG TSCEITGFGK ENSTDYLYPE QLKMTVVKLI SHRECQQPHY YGSEVTTKML CAADPQWKTD SCQGDSGGPL VCSLQGRMTL TGIVSWGRGC ALKDKPGVYT RVSHFLPWIR SHTKEENGLA L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards