Tryptase alpha/beta-1 (TPSAB1)

About Tryptase alpha/beta-1

Tryptase alpha/beta-1 (TPSAB1) is a protein from Homo sapiens identified by UniProt accession Q15661, 275 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	Tryptase alpha/beta-1
UniProt accession	Q15661
Gene	TPSAB1
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (119)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.17
blood protein measurement · score 0.17
cutaneous melanoma · score 0.15
glioblastoma multiforme · score 0.10
urticaria · score 0.10
tryptase beta-2 measurement · score 0.09
appendicular lean mass · score 0.09
Immunodeficiency due to a late component of complements deficiency · score 0.09
systemic mastocytosis · score 0.09
DNA methylation · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15661-F1	alphafold	PREDICTED	91.31	—

Amino-acid sequence (275 residues)

MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards