About Serine hydroxymethyltransferase, mitochondrial
Serine hydroxymethyltransferase, mitochondrial (SHMT2) is a protein
from Homo sapiens identified by UniProt accession
P34897, 504 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Serine hydroxymethyltransferase, mitochondrial |
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| UniProt accession | P34897 |
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| Gene | SHMT2 |
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| Organism | Homo sapiens |
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| Length | 504 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (209)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities · score 0.72
- Neurodevelopmental disorder · score 0.33
- schizophrenia · score 0.23
- genetic disorder · score 0.19
- autism spectrum disorder · score 0.17
- IGF-1 measurement · score 0.15
- bipolar disorder · score 0.14
- obsessive-compulsive disorder · score 0.14
- Tourette syndrome · score 0.14
- attention deficit hyperactivity disorder · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P34897-F1 | alphafold | PREDICTED | 93.29 | — |
Amino-acid sequence (504 residues)
MLYFSLFWAA RPLQRCGQLV RMAIRAQHSN AAQTQTGEAN RGWTGQESLS DSDPEMWELL QREKDRQCRG LELIASENFC SRAALEALGS CLNNKYSEGY PGKRYYGGAE VVDEIELLCQ RRALEAFDLD PAQWGVNVQP YSGSPANLAV YTALLQPHDR IMGLDLPDGG HLTHGYMSDV KRISATSIFF ESMPYKLNPK TGLIDYNQLA LTARLFRPRL IIAGTSAYAR LIDYARMREV CDEVKAHLLA DMAHISGLVA AKVIPSPFKH ADIVTTTTHK TLRGARSGLI FYRKGVKAVD PKTGREIPYT FEDRINFAVF PSLQGGPHNH AIAAVAVALK QACTPMFREY SLQVLKNARA MADALLERGY SLVSGGTDNH LVLVDLRPKG LDGARAERVL ELVSITANKN TCPGDRSAIT PGGLRLGAPA LTSRQFREDD FRRVVDFIDE GVNIGLEVKS KTAKLQDFKS FLLKDSETSQ RLANLRQRVE QFARAFPMPG FDEH
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