Retinoic acid receptor RXR-alpha (RXRA)

About Retinoic acid receptor RXR-alpha

Retinoic acid receptor RXR-alpha (RXRA) is a protein from Homo sapiens identified by UniProt accession P19793, 462 residues long. MolForge cross-references it against 0 known binders and 641 disease associations.

Target properties

Protein name	Retinoic acid receptor RXR-alpha
UniProt accession	P19793
Gene	RXRA
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (13)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (641)

Diseases linked to this target (Open Targets).

psoriasis · score 0.59
urinary bladder cancer · score 0.52
sex hormone-binding globulin measurement · score 0.50
Eczematoid dermatitis · score 0.50
Cutaneous T-cell lymphoma · score 0.50
neoplasm · score 0.48
bilirubin measurement · score 0.46
Constipation · score 0.46
skin disease · score 0.45
lymphoma · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P19793-F1	alphafold	PREDICTED	75.39	—

Amino-acid sequence (462 residues)

MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP ISTLSSPING MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP VSSSEDIKPP LGLNGVLKVP AHPSGNMASF TKHICAICGD RSSGKHYGVY SCEGCKGFFK RTVRKDLTYT CRDNKDCLID KRQRNRCQYC RYQKCLAMGM KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL AVEPKTETYV EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL TELVSKMRDM QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL EAYCKHKYPE QPGRFAKLLL RLPALRSIGL KCLEHLFFFK LIGDTPIDTF LMEMLEAPHQ MT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards