N-formyl peptide receptor 1 (FPR1)

About N-formyl peptide receptor 1

N-formyl peptide receptor 1 (FPR1) is a protein from Homo sapiens identified by UniProt accession P21462, 350 residues long. MolForge cross-references it against 0 known binders and 397 disease associations.

Target properties

Protein name	N-formyl peptide receptor 1
UniProt accession	P21462
Gene	FPR1
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (397)

Diseases linked to this target (Open Targets).

periodontitis · score 0.46
ovarian cancer · score 0.25
lymphocyte count · score 0.24
pancreatic adenocarcinoma · score 0.23
eosinophil count · score 0.21
neurodegenerative disease · score 0.20
Parkinson disease · score 0.20
multiple sclerosis · score 0.20
lysosomal storage disease · score 0.20
Alzheimer disease · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21462-F1	alphafold	PREDICTED	83.80	—

Amino-acid sequence (350 residues)

METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV AGFRMTHTVT TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF VFTIVDINLF GSVFLIALIA LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW VMALLLTLPV IIRVTTVPGK TGTVACTFNF SPWTNDPKER INVAVAMLTV RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL RVLSFVAAAF FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards