About Nuclear receptor subfamily 4immunitygroup A member 1
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) is a protein
from Homo sapiens identified by UniProt accession
P22736, 598 residues long.
MolForge cross-references it against 0 known binders and
755 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 4immunitygroup A member 1 |
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| UniProt accession | P22736 |
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| Gene | NR4A1 |
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| Organism | Homo sapiens |
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| Length | 598 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (755)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- glioblastoma multiforme · score 0.28
- breast adenocarcinoma · score 0.28
- lung adenocarcinoma · score 0.19
- endometrial cancer · score 0.18
- chronic lymphocytic leukemia · score 0.13
- neoplasm · score 0.12
- cancer · score 0.11
- hepatocellular carcinoma · score 0.11
- breast cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22736-F1 | alphafold | PREDICTED | 66.08 | — |
Amino-acid sequence (598 residues)
MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL PSFSTFMDGY TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS FKFEDFQVYG CYPGPLSGPV DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA SGPPQPPAFF SFSPPTGPSP SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL EGSGILDTPV TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKRTVQKNAK YICLANKDCP VDKRRRNRCQ FCRFQKCLAV GMVKEVVRTD SLKGRRGRLP SKPKQPPDAS PANLLTSLVR AHLDSGPSTA KLDYSKFQEL VLPHFGKEDA GDVQQFYDLL SGSLEVIRKW AEKIPGFAEL SPADQDLLLE SAFLELFILR LAYRSKPGEG KLIFCSGLVL HRLQCARGFG DWIDSILAFS RSLHSLLVDV PAFACLSALV LITDRHGLQE PRRVEELQNR IASCLKEHVA AVAGEPQPAS CLSRLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPPIIDK IFMDTLPF
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