About Retinoic acid receptor RXR-beta
Retinoic acid receptor RXR-beta (RXRB) is a protein
from Homo sapiens identified by UniProt accession
P28702, 533 residues long.
MolForge cross-references it against 0 known binders and
223 disease associations.
Target properties
| Protein name | Retinoic acid receptor RXR-beta |
|---|
| UniProt accession | P28702 |
|---|
| Gene | RXRB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 533 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (223)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.59
- neurodegenerative disease · score 0.53
- Eczematoid dermatitis · score 0.50
- Cutaneous T-cell lymphoma · score 0.49
- neoplasm · score 0.47
- lymphoma · score 0.45
- psoriasis vulgaris · score 0.39
- squamous cell carcinoma · score 0.37
- Kaposi's sarcoma · score 0.37
- skin disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28702-F1 | alphafold | PREDICTED | 70.91 | — |
Amino-acid sequence (533 residues)
MSWAARPPFL PQRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA AAVAGGEQQT PEPEPGEAGR DGMGDSGRDS RSPDSSSPNP LPQGVPPPSP PGPPLPPSTA PSLGGSGAPP PPPMPPPPLG SPFPVISSSM GSPGLPPPAP PGFSGPVSSP QINSTVSLPG GGSGPPEDVK PPVLGVRGLH CPPPPGGPGA GKRLCAICGD RSSGKHYGVY SCEGCKGFFK RTIRKDLTYS CRDNKDCTVD KRQRNRCQYC RYQKCLATGM KREAVQEERQ RGKDKDGDGE GAGGAPEEMP VDRILEAELA VEQKSDQGVE GPGGTGGSGS SPNDPVTNIC QAADKQLFTL VEWAKRIPHF SSLPLDDQVI LLRAGWNELL IASFSHRSID VRDGILLATG LHVHRNSAHS AGVGAIFDRV LTELVSKMRD MRMDKTELGC LRAIILFNPD AKGLSNPSEV EVLREKVYAS LETYCKQKYP EQQGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLEAPH QLA
Explore Retinoic acid receptor RXR-beta with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets