About Retinoic acid receptor RXR-gamma
Retinoic acid receptor RXR-gamma (RXRG) is a protein
from Homo sapiens identified by UniProt accession
P48443, 463 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | Retinoic acid receptor RXR-gamma |
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| UniProt accession | P48443 |
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| Gene | RXRG |
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| Organism | Homo sapiens |
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| Length | 463 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (184)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.59
- neurodegenerative disease · score 0.52
- Eczematoid dermatitis · score 0.50
- Cutaneous T-cell lymphoma · score 0.49
- neoplasm · score 0.48
- age at menarche · score 0.46
- lymphoma · score 0.45
- electrocardiography · score 0.44
- Alzheimer disease · score 0.42
- BMI-adjusted waist circumference · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48443-F1 | alphafold | PREDICTED | 73.85 | — |
Amino-acid sequence (463 residues)
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL EAELAVEPKT ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLETPL QIT
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