Etretinate

Retinoid — DERMATOLOGICALS

Key facts

Etretinate is an ofm drug in the Retinoid class catalogued in DrugCentral. It was first approved by the FDA in 1986. DrugCentral lists 2 molecular targets, including RARA and RXRG. Recorded indications include Psoriasis.

• Approval status: ofm (first approved 1986 by the FDA).
• Drug class: Retinoid.
• Molecular targets: RARA and RXRG (2 listed in DrugCentral).
• Indications: Psoriasis.
• ATC code: D05BB01 (Retinoids for treatment of psoriasis).
• Molecular formula: C23H30O3; molecular weight 354.49 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Psoriasis

Off-label uses (2)

• Disorder of keratinization
• Oral lichen planus

Contraindications (10)

• Benign intracranial hypertension
• Breastfeeding (mother)
• Corneal erosion
• Corneal opacity
• Diabetes mellitus type 2
• Disease of liver
• Drug-induced hepatitis
• Hypertriglyceridemia
• Hypertrophy of bone
• Pregnancy, function

Mechanism & targets

• Established pharmacologic class: Retinoid

Molecular targets (2)

Target	Gene	Action	Activity
Retinoic acid receptor alpha	RARA	agonist	—
Retinoic acid receptor RXR-gamma	RXRG	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1986-09-30	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D05BB01	DERMATOLOGICALS › ANTIPSORIATICS › ANTIPSORIATICS FOR SYSTEMIC USE › Retinoids for treatment of psoriasis

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Etretinate is on its molecule page.

• Molecular formula: C₂₃H₃₀O₃
• Molecular weight: 354.49 g/mol
• CAS number: 54350-48-0
• InChIKey: HQMNCQVAMBCHCO-DJRRULDNSA-N
• PubChem CID: 5282375

CCOC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(C)=C(OC)C=C1C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Etretinate used for?

DrugCentral lists the following indications for Etretinate: Psoriasis.

How does Etretinate work?

Its molecular targets in DrugCentral include RARA (agonist) and RXRG (agonist).

When was Etretinate first approved?

Etretinate was first approved by the FDA in 1986.

What drug class does Etretinate belong to?

Etretinate is in the Retinoid class.

What is the chemical formula of Etretinate?

Etretinate has the molecular formula C23H30O3 and a molecular weight of 354.49 g/mol.

Sources

• DrugCentral drug card 1116 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL464 — compound record and bioactivity
• PubChem CID 5282375 — chemical identifiers
• DrugBank DB00459 — drug record
• FDA UNII 65M2UDR9AG — substance identity
• DailyMed: FDA labels for Etretinate — current prescribing information (label search)
• UniProt P10276 (RARA) — target protein
• UniProt P48443 (RXRG) — target protein

How this page is built: methodology · editorial policy & corrections.