About Solute carrier family 22 member 12
Solute carrier family 22 member 12 (SLC22A12) is a protein
from Homo sapiens identified by UniProt accession
Q96S37, 553 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Solute carrier family 22 member 12 |
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| UniProt accession | Q96S37 |
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| Gene | SLC22A12 |
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| Organism | Homo sapiens |
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| Length | 553 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (164)
Diseases linked to this target (Open Targets).
- gout · score 0.74
- urate measurement · score 0.70
- hereditary renal hypouricemia · score 0.65
- hypouricemia, renal · score 0.51
- hyperuricemia · score 0.50
- type 2 diabetes mellitus · score 0.39
- acquired metabolic disease · score 0.37
- uric acid measurement · score 0.31
- drug use measurement · score 0.28
- body mass index · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96S37-F1 | alphafold | PREDICTED | 86.56 | — |
Amino-acid sequence (553 residues)
MAFSELLDLV GGLGRFQVLQ TMALMVSIMW LCTQSMLENF SAAVPSHRCW APLLDNSTAQ ASILGSLSPE ALLAISIPPG PNQRPHQCRR FRQPQWQLLD PNATATSWSE ADTEPCVDGW VYDRSIFTST IVAKWNLVCD SHALKPMAQS IYLAGILVGA AACGPASDRF GRRLVLTWSY LQMAVMGTAA AFAPAFPVYC LFRFLLAFAV AGVMMNTGTL LMEWTAARAR PLVMTLNSLG FSFGHGLTAA VAYGVRDWTL LQLVVSVPFF LCFLYSWWLA ESARWLLTTG RLDWGLQELW RVAAINGKGA VQDTLTPEVL LSAMREELSM GQPPASLGTL LRMPGLRFRT CISTLCWFAF GFTFFGLALD LQALGSNIFL LQMFIGVVDI PAKMGALLLL SHLGRRPTLA ASLLLAGLCI LANTLVPHEM GALRSALAVL GLGGVGAAFT CITIYSSELF PTVLRMTAVG LGQMAARGGA ILGPLVRLLG VHGPWLPLLV YGTVPVLSGL AALLLPETQS LPLPDTIQDV QNQAVKKATH GTLGNSVLKS TQF
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