Dotinurad

MUSCULO-SKELETAL SYSTEM

Key facts

Dotinurad is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2020. DrugCentral lists 5 molecular targets, including SLC22A12, SLC22A8 and SLC22A6. Recorded indications include Gout and Hyperuricemia.

• Molecular targets: SLC22A12, SLC22A8, SLC22A6 and ABCG2 (5 listed in DrugCentral).
• Indications: Gout and Hyperuricemia.
• ATC code: M04AB06 (Preparations increasing uric acid excretion).
• Molecular formula: C14H9Cl2NO4S; molecular weight 358.19 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Gout
• Hyperuricemia

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Solute carrier family 22 member 12	SLC22A12	inhibitor	IC50 7.43
Solute carrier family 22 member 8	SLC22A8	inhibitor	IC50 5.88
Solute carrier family 22 member 6	SLC22A6	inhibitor	IC50 5.39
ATP-binding cassette sub-family G member 2	ABCG2	inhibitor	IC50 5.38
Cytochrome P450 2C9	CYP2C9	inhibitor	IC50 5.24

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2020-01-23	PMDA	—	Fuji Yakuhin

ATC classification

ATC code	Therapeutic hierarchy
M04AB06	MUSCULO-SKELETAL SYSTEM › ANTIGOUT PREPARATIONS › ANTIGOUT PREPARATIONS › Preparations increasing uric acid excretion

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dotinurad is on its molecule page.

• Molecular formula: C₁₄H₉Cl₂NO₄S
• Molecular weight: 358.19 g/mol
• CAS number: 1285572-51-1
• InChIKey: VOFLAIHEELWYGO-UHFFFAOYSA-N
• PubChem CID: 51349053

C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dotinurad used for?

DrugCentral lists the following indications for Dotinurad: Gout and Hyperuricemia.

How does Dotinurad work?

Its molecular targets in DrugCentral include SLC22A12 (inhibitor), SLC22A8 (inhibitor), SLC22A6 (inhibitor) and ABCG2 (inhibitor).

When was Dotinurad first approved?

Dotinurad was first approved by the PMDA in 2020.

What is the chemical formula of Dotinurad?

Dotinurad has the molecular formula C14H9Cl2NO4S and a molecular weight of 358.19 g/mol.

Sources

• DrugCentral drug card 5425 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4594446 — compound record and bioactivity
• PubChem CID 51349053 — chemical identifiers
• DrugBank DB16145 — drug record
• FDA UNII 305EB53128 — substance identity
• UniProt Q96S37 (SLC22A12) — target protein
• UniProt Q8TCC7 (SLC22A8) — target protein
• UniProt Q4U2R8 (SLC22A6) — target protein
• UniProt Q9UNQ0 (ABCG2) — target protein
• UniProt P11712 (CYP2C9) — target protein

How this page is built: methodology · editorial policy & corrections.